Ke hoʻololi nei i ka ʻike ʻana o C. diff: Hoʻokō i ka ʻakomi piha ʻana, Laʻana-a-Pane Molecular Diagnostics

He aha ke kumu o ka maʻi C. Diff?

1. Hoʻokumu ʻia ka maʻi diff e kahi bacteria i ʻike ʻia ʻo Clostridioides difficile (C. difficile), ka mea maʻamau e noho me ka ʻino ʻole i loko o nā ʻōpū. Eia nō naʻe, i ka wā e hoʻopilikia ʻia ai ke kaulike bacteria o ka ʻōpū, hoʻohana pinepine ʻia nā antibiotic ākea.C. paʻakikīhiki ke ulu nui a hana i nā toxins, e alakaʻi ana i ka maʻi.

Aia kēia bacteria ma nā ʻano toxigenic a me nā ʻano non-toxigenic, akā ʻo nā ʻano toxigenic wale nō (toxins A a me B) ke kumu o ka maʻi. Hoʻoulu lākou i ka mumū ma ka hoʻopilikia ʻana i nā cell epithelial intestinal. ʻO Toxin A kahi enterotoxin nui e hōʻino i ka uhi ʻōpū, e hoʻonui ana i ka permeability, a me ka huki ʻana i nā cell immune e hoʻokuʻu i nā cytokines inflammatory. ʻO Toxin B, kahi cytotoxin ikaika loa, e kuhikuhi ana i ka actin cytoskeleton o nā cell, e alakaʻi ana i ka hoʻopuni ʻana o nā cell, ka wehe ʻana, a me ka make ʻana o nā cell. I ka hui pū ʻana, hoʻoulu kēia mau toxins i ka hōʻino ʻana o nā ʻiʻo a me kahi pane pale ikaika, e hōʻike ana e like me ka colitis, ka diarrhea, a i nā hihia koʻikoʻi, pseudomembranous colitis - kahi mumū koʻikoʻi o ka colon.

Pehea e laha ai ʻo C. Diff?

1. Hoʻolaha maʻalahi ka diff. Loaʻa ia ma nā haukapila, loaʻa pinepine i nā ICU, ma nā lima o nā limahana haukapila, ma nā papahele haukapila a me nā ʻauamo lima, ma nā ana wela uila, a me nā lako lapaʻau ʻē aʻe…

Nā Kumu Pilikia no ka Maʻi C. Diff

• Ka hoʻopaʻa ʻia ʻana i ka haukapila no ka manawa lōʻihi;
• Ka lāʻau lapaʻau antimicrobial;
• Nā mea hana chemotherapy;
• ʻO ke ʻoki kino hou loa (nā lima ʻōpū,ka ʻoki ʻōpū, ʻoki kino kolona);
• ʻO ka meaʻai naso-gastric;
• Ka maʻi C. diff ma mua;

Nā hōʻailona o ka maʻi C. Diff

Hiki i ka maʻi C. diff ke lilo i mea ʻoluʻolu ʻole loa. Loaʻa i ka hapa nui o ka poʻe ka maʻi diarrhea a me ka ʻeha ʻole i loko o ka ʻōpū. ʻO nā hōʻailona maʻamau ka mea:ka maʻi kahe, ʻeha ʻōpū, nausea, nele i ka makemake, kuni.

I ka lilo ʻana o ka maʻi C. diff i mea koʻikoʻi, e ulu ana kahi ʻano paʻakikī o C. diff i ʻike ʻia ʻocolitis, pseudomembranous enteritis a me ka make.

Ka ʻike ʻana i ka maʻi C. Diff

Moʻomeheu bacteriaʻAʻole naʻe i maʻalahi akāka lōʻihi o ka manawa (2-5 lā), ʻaʻole hiki ke hoʻokaʻawalenā ʻano toxigenic a me nā non-toxigenic;

Moʻomeheu Toxin:ʻike i nā ʻano toxigenic e hoʻoulu ai i ka maʻi akā e hoʻopau ana i ka manawa (3-5 mau lā) a emi iki ka naʻau;

Ka ʻIke ʻana iā GDH:wikiwiki (1-2 hola) a kūpono hoʻi i ke kumukūʻai, ʻike nui ʻia akā ʻaʻole hiki ke hoʻokaʻawale i nā ʻano toxigenic a me nā non-toxigenic;

Hoʻāʻo Neutralization Cytotoxicity Cell (CCNA):ʻike i ka toxin A a me B me ke koʻikoʻi kiʻekiʻe akā e hoʻopau ana i ka manawa (2-3 mau lā), a koi aku i nā pono kūikawā a me nā limahana i aʻo ʻia;

ʻO ka Toxin A/B ELISA: Hoʻāʻo maʻalahi a wikiwiki hoʻi (1-2 hola) me ka ʻike haʻahaʻa a me nā hopena wahaheʻe pinepine;

Nā Hoʻāʻo Hoʻonui ʻAkika Nukleika (NAAT)Wikiwiki (1-3 hola) a koʻikoʻi loa a kikoʻī hoʻi, e ʻike ana i nā genes kuleana no ka hana ʻana i nā mea ʻawahia;

Eia kekahi, nā hoʻokolohua kiʻi e nānā i nā ʻōpū, e like meNā scan CTa meNā kukuna X, hiki ke hoʻohana ʻia e kōkua i ka ʻike ʻana iā C. diff a me nā pilikia o C. diff, e like me ka colitis.

Ka mālama ʻana i ka maʻi C. Diff

Nui nā koho lapaʻau i loaʻa no ka maʻi C. diff. Eia nā koho maikaʻi loa:

• Hoʻohana pinepine ʻia nā lāʻau antibiotic waha e like me vancomycin, metronidazole a i ʻole fidaxomicin no ka mea hiki i ka lāʻau ke hele ma o ka ʻōnaehana hoʻoheheʻe a hiki i ka colon kahi e noho ai ka bacteria C. diff.
• Hiki ke hoʻohana ʻia ka metronidazole intravenous no ka mālama ʻana inā koʻikoʻi ka maʻi C. diff.
• Ua hōʻike ʻia ka pono o nā hoʻoili microbiota fecal i ka mālama ʻana i nā maʻi C. diff pinepine a me nā maʻi C. diff koʻikoʻi i pane ʻole i nā antibiotics.
• Pono paha ke ʻoki kino no nā hihia koʻikoʻi.

ʻO ka d houhoʻonā anagnostic mai MMT

I ka pane ʻana i ka pono no ka ʻike wikiwiki a pololei hoʻi o C. difficile, ke hoʻolauna nei mākou i kā mākou Nucleic Acid Detection Kit hou no ka Clostridium difficile toxin A/B gene, e hoʻoikaika ana i nā loea olakino e hana i ka ʻike mua a pololei a kākoʻo i ke kaua ʻana i nā maʻi i loaʻa i ka haukapila.

• ʻIke Kiʻekiʻe: ʻIke i ka haʻahaʻa e like me200 CFU/mL,;
• Ka Hoʻolālā Pololei: Kuhikuhi pololei i ka C. paʻakikīgene toxin A/B, e hoʻēmi ana i nā hopena wahaheʻe;
• Ka ʻIke Pololei ʻana i nā Maʻi PāpaʻiHoʻohana i ka hoʻāʻo ʻana o ka waikawa nucleic e ʻike pololei i nā genes toxin, e hoʻokumu ana i kahi kūlana gula no nā diagnostics.
• Hoʻopili piha menā mea hana PCR maʻamau e kamaʻilio ana i nā labs hou aʻe;

Hoʻonā Laʻana-a-Pane ma lunaHoʻāʻo Macro & Micro'sAIO800Keʻena Hoʻokolohua PCR Kelepona

ʻAna Hana Hoʻomāmā Laʻana - Hoʻouka pololei i nā ʻōmole laʻana kumu (1.5–12 mL), e hoʻopau ana i ka pipetting lima. Hoʻomāmā piha ʻia ka unuhi ʻana, ka hoʻonui ʻana, a me ka ʻike ʻana, e hoʻemi ana i ka manawa hana lima a me ka hewa kanaka.

• Palekana Hoʻohaumia 11-Papa - ʻO ke kahe ʻana o ke ea kuhikuhi, ke kaomi maikaʻi ʻole, ka kānana HEPA, ka sterilization UV, nā hopena i hoʻopaʻa ʻia, a me nā palekana i hoʻohui ʻia e pale aku i nā limahana a hōʻoia i nā hopena hilinaʻi i ka wā o ka hoʻāʻo ʻana i ka throughput kiʻekiʻe.

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