ʻO ka Polymorphism Genetic ALDH

ʻO ka gene ALDH2 (acetaldehyde dehydrogenase 2), aia ma ka chromosome kanaka 12. Loaʻa iā ALDH2 ka hana esterase, dehydrogenase a me ka reductase i ka manawa like. Ua hōʻike ʻia nā haʻawina he enzyme metabolic ʻo ALDH2 o ka nitroglycerin, ka mea e hoʻololi i ka nitroglycerin i nitric oxide, a laila e hoʻomaha ai i nā kīʻaha koko a hoʻomaikaʻi i nā maʻi kahe koko. Eia nō naʻe, aia nā polymorphisms i loko o ka gene ALDH2, kahi i hoʻonui nui ʻia ma Asia Hikina. Loaʻa i ka wild-type ALDH2*1/*1 GG ka hiki ke metabolic ikaika, ʻoiai ʻo ke ʻano heterozygous he 6% wale nō o ka hana enzyme wild-type, a ʻo ke ʻano homozygous mutant kokoke ʻole ka hana enzyme, me ka metabolism nāwaliwali loa a ʻaʻole hiki ke hoʻokō i ka hopena i makemake ʻia, no laila e hōʻeha ai i ke kino kanaka.