ALDH Genetic Polymorphism

Loaʻa ka gene ALDH2 (acetaldehyde dehydrogenase 2), ma ka chromosome kanaka 12. Loaʻa i ka ALDH2 ka hana esterase, dehydrogenase a me reductase i ka manawa like. Ua hōʻike ʻia nā haʻawina ʻo ALDH2 he enzyme metabolic o ka nitroglycerin, nāna e hoʻohuli i ka nitroglycerin i nitric oxide, a laila hoʻomaha i nā kīʻaha koko a hoʻomaikaʻi i nā maʻi kahe koko. Eia nō naʻe, aia nā polymorphism i loko o ka gene ALDH2, ka mea nui i hoʻopaʻa ʻia ma Asia Hikina. ʻO ka ALDH2 * 1 / * 1 GG ʻano ʻāhiu ikaika loa, ʻoiai ʻo ka heterozygous ʻano he 6% wale nō o ka hana enzyme wild-type, a ʻo ka ʻano homozygous mutant he aneane ʻole ka hana enzyme, me ka metabolism nāwaliwali loa a ʻaʻole hiki ke hoʻokō i ka hopena i makemake ʻia, no laila e hōʻeha ai i ke kino o ke kanaka.