Lāʻau Palekana ʻAspirin

ʻO ka ʻAspirin, ma ke ʻano he lāʻau anti-platelet aggregation kūpono, ua hoʻohana nui ʻia i ka pale ʻana a me ka mālama ʻana i nā maʻi cardiovascular a me cerebrovascular. Ua ʻike ʻia ma ke aʻo ʻana ua ʻike ʻia kekahi mau maʻi ʻaʻole hiki ke kāohi pono i ka hana o nā platelets ʻoiai ka hoʻohana ʻana i ka aspirin haʻahaʻa lōʻihi, ʻo ia hoʻi, ke kūʻē ʻana i ka aspirin (AR). ʻO ka helu ma kahi o 50%-60%, a he ʻokoʻa lāhui maopopo. He kuleana koʻikoʻi ko Glycoprotein IIb/IIIa (GPI IIb/IIIa) i ka hōʻiliʻili platelet a me ka thrombosis koʻikoʻi ma nā wahi o ka ʻeha vascular. Ua hōʻike ʻia nā haʻawina he kuleana koʻikoʻi ko nā polymorphisms gene i ke kūʻē ʻana i ka aspirin, e kālele nui ana i nā polymorphisms gene GPIIIa P1A1/A2, PEAR1 a me PTGS1. ʻO GPIIIa P1A2 ke gene nui no ke kūʻē ʻana i ka aspirin. Hoʻololi nā mutations i loko o kēia gene i ke ʻano o nā mea loaʻa GPIIb/IIIa, e hopena ana i ka pilina ma waena o nā platelets a me ka hōʻiliʻili platelet. Ua ʻike ʻia ma ke aʻo ʻana ua ʻoi aku ka nui o ke alapine o nā alleles P1A2 i nā poʻe maʻi kūʻē i ka aspirin ma mua o nā poʻe maʻi i loaʻa ka aspirin, a ʻo nā poʻe maʻi me nā mutations homozygous P1A2/A2 he haʻahaʻa ka hopena ma hope o ka lawe ʻana i ka aspirin. ʻO nā poʻe maʻi me nā alleles P1A2 mutant e hana ʻia ana i ka stenting he subacute thrombotic event rate ʻelima mau manawa o nā poʻe maʻi P1A1 homozygous wild-type, e koi ana i nā dosis kiʻekiʻe o ka aspirin e hoʻokō i nā hopena anticoagulant. Pane maikaʻi ka allele PEAR1 GG i ka aspirin, a ʻo nā poʻe maʻi me ka genotype AA a i ʻole AG e lawe ana i ka aspirin (a i ʻole i hui pū ʻia me clopidogrel) ma hope o ka hoʻokomo ʻana o ka stent he kiʻekiʻe ka myocardial infarction a me ka make. Loaʻa i ka genotype PTGS1 GG kahi pilikia kiʻekiʻe o ke kūʻē ʻana i ka aspirin (HR: 10) a me kahi hanana kiʻekiʻe o nā hanana cardiovascular (HR: 2.55). Loaʻa i ka genotype AG kahi pilikia kūpono, a pono e uku pono ʻia ka hopena o ka lāʻau aspirin. ʻOi aku ka maʻalahi o ka genotype AA i ka aspirin, a haʻahaʻa ka hanana o nā hanana cardiovascular. Hōʻike wale nā ​​​​hopena ʻike o kēia huahana i nā hopena ʻike o nā genes PEAR1, PTGS1, a me GPIIIa kanaka.