ʻO ka lāʻau palekana aspirin

ʻO Aspirin, ma ke ʻano he lāʻau anti-platelet aggregation maikaʻi, ua hoʻohana nui ʻia i ka pale ʻana a me ka mālama ʻana i nā maʻi cardiovascular a me ka cerebrovascular. Ma kahi o 50% -60% ka pākēneka, a aia nā ʻokoʻa lāhui. He kuleana koʻikoʻi ka Glycoprotein IIb/IIIa (GPI IIb/IIIa) i ka hōʻiliʻili platelet a me ka thrombosis acute ma nā wahi o ka hōʻeha vascular. Ua hōʻike ʻia nā haʻawina he hana koʻikoʻi nā gene polymorphisms i ka pale ʻana i ka aspirin, ka mea nui i ka GPIIIa P1A1/A2, PEAR1 a me PTGS1 gene polymorphisms. ʻO GPIIIa P1A2 ka gene nui no ka pale ʻana i ka aspirin. Hoʻololi ka hoʻololi ʻana i kēia moʻo i ke ʻano o nā mea loaʻa GPIIb/IIIa, ka hopena i ka pilina ma waena o nā platelets a me ka hōʻuluʻulu platelet. Ua ʻike ka haʻawina ʻoi aku ka kiʻekiʻe o ke alapine o nā alleles P1A2 i nā poʻe maʻi e kū'ē i ka aspirin ma mua o ka poʻe maʻi e pili ana i ka aspirin, a ʻo nā poʻe maʻi me ka homozygous mutations P1A2/A2 he maikaʻi ʻole ma hope o ka lawe ʻana i ka aspirin. ʻO nā poʻe maʻi me nā alahele P1A2 mutant e hele ana i ka stenting he subacute thrombotic event rate he ʻelima mau manawa ma mua o ka P1A1 homozygous wild-type maʻi, e koi ana i nā kiʻekiʻe o ka aspirin e loaʻa ai nā hopena anticoagulant. ʻO ka PEAR1 GG allele e pane maikaʻi i ka aspirin, a me ka poʻe maʻi me AA a i ʻole AG genotype e lawe nei i ka aspirin (a i hui pū ʻia me clopidogrel) ma hope o ka hoʻokomo ʻana i ka stent he kiʻekiʻe ka myocardial infarction a me ka make. Loaʻa i ka PTGS1 GG genotype kahi pilikia nui o ka pale ʻana i ka aspirin (HR: 10) a me kahi kiʻekiʻe o nā hanana cardiovascular (HR: 2.55). ʻO ka genotype AG he pilikia kūpono, a pono e nānā pono i ka hopena o ka lāʻau aspirin. ʻOi aku ka maʻalahi o ka genotype AA i ka aspirin, a ʻoi aku ka haʻahaʻa o nā hanana cardiovascular. Hōʻike nā hopena ʻike o kēia huahana i nā hopena ʻike o nā genes PEAR1, PTGS1, a me GPIIIa kanaka.