ʻO ka Mycobacterium Tuberculosis Rifampicin Resistance

ʻO ka wehewehe pōkole:

He kūpono kēia pahu no ka ʻike qualitative o ka homozygous mutation i loko o ka 507-533 amino acid codon māhele o ka rpoB gene i kumu kūʻē ʻo Mycobacterium tuberculosis rifampicin.


Huahana Huahana

Huahana Huahana

Inoa mea kūʻai

HWTS-RT074A-Mycobacterium Tuberculosis Rifampicin Resistance Detection Kit (Fluorescence PCR)

Epidemiology

Ua hoʻohana nui ʻia ka Rifampicin i ka mālama ʻana i nā maʻi maʻi maʻi maʻi mai ka hopena o 1970s, a he hopena koʻikoʻi.ʻO ia ke koho mua e hoʻopōkole i ka chemotherapy o nā maʻi maʻi maʻi maʻi pulmonary.ʻO ke kūʻē ʻana o Rifampicin ma muli o ka hoʻololi ʻana o ka gene rpoB.ʻOiai ke puka mau nei nā lāʻau anti-tuberculosis hou, a ke hoʻomau nei ka maikaʻi o ka lāʻau lapaʻau o ka poʻe maʻi maʻi maʻi pulmonary tuberculosis, aia nō ka nele o nā lāʻau anti-tuberculosis, a ʻoi aku ka kiʻekiʻe o ke ʻano o ka hoʻohana ʻana i ka lāʻau lapaʻau i ka lāʻau lapaʻau.Akaka, ka Mycobacterium tuberculosis i loko o nā mea maʻi me ka pulmonary tuberculosis hiki ole loa pepehi i ka manawa kūpono, ka mea hope alakai i ka likeʻole degere o ka lāʻau kū'ē i loko o ke kino o ka mea maʻi, hooloihi aku i ka papa o ka maʻi, a hoʻonui i ka pilikia o ka make o ka mea maʻi.He kūpono kēia pahu no ka hōʻoia kōkua o ka Mycobacterium tuberculosis maʻi a me ka ʻike ʻana i ka rifampicin resistance gene, he mea kōkua e hoʻomaopopo i ke kūʻē ʻana i ka lāʻau o ka mycobacterium tuberculosis i hoʻopili ʻia e nā maʻi, a me ka hāʻawi ʻana i nā mea kōkua no ke alakaʻi ʻana i ka lāʻau lapaʻau.

Epidemiology

 

Inoa Pahuhi Mea hoolaha Quencher
Paʻa PaʻaA Paʻa PaʻaB Paʻa PaʻaC
rpoB 507-514 rpoB 513-520 IS6110 FAM ʻAʻohe
rpoB 520-527 rpoB 527-533 / CY5 ʻAʻohe
/ / Ka hooponopono kuloko HEX(VIC) ʻAʻohe

 

Nā ʻāpana ʻenehana

Waihona

≤-18 ℃ I ka pōʻeleʻele

Kau-ola

9 mahina

ʻAno Hoʻohālike

Sputum

CV

<5%

LoD

ʻano ʻāhiu kūʻē rifampicin: 2x103bacteria/mL

homozygous mutant: 2x103bacteria/mL

kikoo

ʻIke ʻo ia i ka mycobacterium tuberculosis ʻano ʻāhiu a me nā pae hoʻololi o nā genes kū'ē lāʻau ʻē aʻe e like me katG 315G>C\A, InhA-15C>T, hōʻike nā hopena hōʻike ʻaʻole kūʻē i ka rifampicin, ʻo ia hoʻi, ʻaʻohe cross-reactivity.

Nā mea hana pili:

SLAN-96P Pūnaehana PCR manawa maoli(Hongshi Medical Technology Co., Ltd. )

Holo Hana


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