ʻO ke kū'ē ʻana o ka Mycobacterium Tuberculosis Nucleic Acid a me Rifampicin

ʻO Mycobacterium tuberculosis, i kapa ʻia ʻo Tubercle bacillus, TB, ka bacteria pathogenic e hoʻoulu ai i ka maʻi tuberculosis. I kēia manawa, ʻo nā lāʻau lapaʻau anti-tuberculosis laina mua i hoʻohana pinepine ʻia e komo pū me isoniazid, rifampicin a me hexambutol, a pēlā aku. ʻO nā lāʻau lapaʻau anti-tuberculosis laina lua e komo pū ana me fluoroquinolones, amikacin a me kanamycin, a pēlā aku. ʻO nā lāʻau lapaʻau hou i hoʻomohala ʻia ʻo linezolid, bedaquiline a me delamani, a pēlā aku. Eia naʻe, ma muli o ka hoʻohana hewa ʻana o nā lāʻau anti-tuberculosis a me nā ʻano o ke ʻano o ka paia cell o mycobacterium tuberculosis, hoʻomohala ka mycobacterium tuberculosis i ke kūʻē ʻana i ka lāʻau i nā lāʻau anti-tuberculosis, kahi e lawe mai ai i nā pilikia koʻikoʻi i ka pale ʻana a me ka mālama ʻana i ka maʻi tuberculosis.

Ua hoʻohana nui ʻia ʻo Rifampicin i ka mālama ʻana i nā maʻi tuberculosis pulmonary mai ka hopena o nā makahiki 1970, a he hopena koʻikoʻi kona. ʻO ia ke koho mua e hoʻopōkole i ka chemotherapy o nā maʻi tuberculosis pulmonary. ʻO ke kūʻē ʻana o Rifampicin ke kumu nui o ka mutation o ka gene rpoB. ʻOiai ke puka mau nei nā lāʻau anti-tuberculosis hou, a ua hoʻomau ka maikaʻi o ka lapaʻau o nā maʻi tuberculosis pulmonary, aia nō ka nele o nā lāʻau anti-tuberculosis, a ʻo ke ʻano o ka hoʻohana ʻana i nā lāʻau lapaʻau i kūpono ʻole i ka lapaʻau he kiʻekiʻe loa. ʻIke loa, ʻaʻole hiki ke pepehi piha ʻia ka Mycobacterium tuberculosis i nā maʻi me ka tuberculosis pulmonary i ka manawa kūpono, kahi e alakaʻi ai i nā ʻano like ʻole o ke kūʻē ʻana i ka lāʻau i ke kino o ka mea maʻi, hoʻolōʻihi i ke ala o ka maʻi, a hoʻonui i ka pilikia o ka make o ka mea maʻi.