ʻIke koʻikoʻi ʻo BCR-ABL no ka mālama ʻana iā CML

ʻO ka maʻi myelogenous leukemia mau (CML) kahi maʻi clonal malignant o nā cell kumu hematopoietic. ʻOi aku ma mua o 95% o nā maʻi CML e lawe ana i ka chromosome Philadelphia (Ph) i loko o kā lākou mau cell koko. A ua hoʻokumu ʻia ka gene fusion BCR-ABL e kahi translocation ma waena o ka ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ma ka lima lōʻihi o ka chromosome 9 (9q34) a me ka gene breakpoint cluster region (BCR) ma ka lima lōʻihi o ka chromosome 22 (22q11). ʻO kāna protein fusion i hoʻopili ʻia e kēia gene he hana tyrosine kinase (TK), a hoʻāla i kona mau ala hōʻailona ma lalo (e like me RAS, PI3K, a me JAK/STAT) e hoʻolaha i ka mahele cell a kāohi i ka apoptosis cell, e hoʻonui ana i nā cell i ka malignant, a pēlā e hoʻoulu ai i ka hanana o CML.

ʻO ka gene fusion BCR-ABL, he mea nui ia i ka hoʻomohala ʻana o CML, lawelawe ʻo ia ma ke ʻano he māka diagnostic koʻikoʻi. o CML. Kōkua kona ʻike ʻana i ka nānā ʻana i ka mea maʻi'ka pane a ka hopena i nā tyrosine kinase inhibitors (TKIs) a wānana i ka hoʻi hou ʻana o ka leukemia, he mea nui ia no ka hoʻokele pono ʻana i ka maʻi CML.

BCR-ABL kanakaPahu ʻIke Hoʻololi Gene Fusionmai Macro & Micro-Test no ka ʻike pono ʻana o ka BCR-ABL i nā poʻe maʻi CML, kōkua i ka ʻike ʻana o CML a alakaʻi i nā lāʻau lapaʻau i kuhikuhi ʻia e hoʻomaikaʻi i nā hoʻolālā therapeutic no ka hoʻokele maʻi kūpono.BCR-ABL fusion gene, ka meaʻo iakoʻikoʻii ka hoʻomohala ʻana o CML,lawelawe ma ke ʻano he māka diagnostic koʻikoʻiofCMLKōkua kona ʻike ʻana inānāmea maʻi'spane i nā mea hoʻopaʻa tyrosine kinase (TKIs)a mewānana i ka hoʻi hou ʻana o ka leukemia, ʻo ia hoʻimea nuito kūponoCMLka mālama ʻana i ka mea maʻi.

Pahu ʻIke Hoʻololi Gene BCR-ABL Fusion Kanaka mai Macro & Micro-Test no ka ʻike ʻana i ka BCR-ABL i nā poʻe maʻi CML, nā kōkuaCMLhōʻailonaa menā alakaʻinā lāʻau lapaʻau i kuhikuhi ʻiatohoʻomaikaʻienā hoʻolālā therapeutic no ka hoʻokele maʻi kūpono.

ʻIke pihaDhoʻomaopopo ʻana:I ka manawa likeʻike ʻanano3nā genes fusion maʻamau (P210, P190, P230)noka uhi ākea a meka pale ʻana mai nā hihia i hala ʻole;

ʻIke Kiʻekiʻe:ʻIke ka mana wai i nā genes fusionme LoDo 1000 kope/mL,a me ka mana lyophilizedof 500 kope/mL;

Maikaʻi loaApololei: Ikūlokokaohia me ka enzyme UNG e pale aku i nā hopena wahaheʻe& nā mea maikaʻi ʻole;

Ka hana maʻalahi a me ka pono:Hana ʻana i ka paipu pani,manuahi o nā huahanaka hana ma hope,a meʻike ʻanai loko60 mau minukenonā hopena kūpono a hilinaʻi hoʻi;

ʻOi akuNā koho：Nā mana wai a me nā lyophilized no nā koho a nā mea kūʻai aku;

Hoʻohālikelike ākea:Kūlike me ka hapa nui o nā ʻōnaehana PCR no ka hiki ke komo i ka lab ākea.