ʻIke koʻikoʻi BCR-ABL no ka Lapaʻau CML

ʻO ka myelogenousleukemia maʻamau (CML) he maʻi maʻi clonal ʻino o nā cell stem hematopoietic. ʻOi aku ma mua o 95% o nā maʻi CML e lawe i ka chromosome Philadelphia (Ph) i loko o kā lākou mau koko. A ʻo ka BCR-ABL fusion gene i hoʻokumu ʻia e ka unuhi ʻana ma waena o ka ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ma ka lima lōʻihi o ka chromosome 9 (9q34) a me ka ʻāpana ʻāpana ʻāpana (BCR) gene ma ka lima lōʻihi o ka chromosome 22 (22q11). ʻO kāna pūmua fusion i hoʻopaʻa ʻia e kēia ʻano he hana tyrosine kinase (TK), a hoʻāla i kāna mau ala hōʻailona i lalo (e like me RAS, PI3K, a me JAK/STAT) e hoʻoikaika i ka māhele cell a keʻakeʻa i ka apoptosis cell, e hoʻonui nui ai nā cell, a ma laila ke kumu o ka CML.

ʻO ka BCR-ABL fusion gene, ka mea nui i ka hoʻomohala ʻana o CML, lawelawe ma ke ʻano he hōʻailona diagnostical o CML. Kōkua kona ʻike ʻana i ka nānā ʻana i ka mea maʻi's pane i ka tyrosine kinase inhibitors (TKIs) a wānana i ka maʻi maʻi leukemia, he mea nui ia i ka hoʻokele maʻi CML pono.

Kanaka BCR-ABLʻO Fusion Gene Mutation Detection Kitmai Macro & Micro-Test no ka ʻike pono ʻana i ka BCR-ABL i nā maʻi CML, kōkua i ka hōʻailona CML a alakaʻi i nā lāʻau lapaʻau i manaʻo ʻia e hoʻolālā i nā hoʻolālā lapaʻau no ka hoʻokele maʻi maikaʻi.BCR-ABL fusion gene, ka meaʻo iamea nuii ka hoʻomohala ʻana o CML,lawelawe ʻo ia ma ke ʻano he kī diagnostic markerofCML. Kōkua kona ʻikekiaʻihoomanawanui'ska pane ʻana i ka tyrosine kinase inhibitors (TKIs)awānana i ka hoʻi hou ʻana o ka maʻi leukemia, ʻo ia hoʻimea nuito ponoCMLhooponopono ma'i.

ʻO ke kanaka BCR-ABL Fusion Gene Mutation Detection Kit mai Macro & Micro-Test no ka ʻike pono ʻana i ka BCR-ABL i nā maʻi CML, kōkuaCMLhōʻailonaaalakainā lāʻau lapaʻau i manaʻo ʻiatooptimizenā hoʻolālā lāʻau lapaʻau no ka hoʻokele maʻi maikaʻi.

Hoʻopiha pihaDetection:Hoʻokahi manawaʻike makano ka mea3nā genes fusion maʻamau (P210, P190, P230)no ka meauhi ākea aka pale ʻana i nā hihia i hala;

ʻIke Kiʻekiʻe:ʻIke ka mana wai i nā genes fusionme LoDo 1000 kope/mL,a ka lyophilized versionof 500 kope/mL;

maikaʻi loaApololei: Ikūwahohoʻomalua me ka enzyme UNG e pale aku i ka hoʻopunipuni&nā mea ʻino;

Hana maʻalahi a me ka pono:ʻO ka hana ʻana o ka paipu paʻa,manuahi o nā huahanahana hope,aʻike makai loko60 minukeno ka meanā hopena kūpono a hilinaʻi;

ʻOi akuNā koho：Nā ʻano wai a me nā lyophilized no nā koho o nā mea kūʻai aku;

Kūlike ākea:Kūpono me ka hapa nui o nā ʻōnaehana PCR no ka loaʻa ʻana o ka lab ākea.