ʻO ke kanaka BCR-ABL Fusion Gene Mutation

ʻO ka wehewehe pōkole:

He kūpono kēia pahu no ka ʻike qualitative o p190, p210 a me p230 isoforms o ka BCR-ABL fusion gene i loko o nā laʻana o ka iwi iwi kanaka.


Huahana Huahana

Huahana Huahana

Inoa mea kūʻai

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR )

Epidemiology

ʻO ka myelogenousleukemia maʻamau (CML) he maʻi maʻi clonal ʻino o nā cell stem hematopoietic.ʻOi aku ma mua o 95% o nā maʻi CML e lawe i ka chromosome Philadelphia (Ph) i loko o kā lākou mau koko.ʻO ka pathogenesis nui o CML penei: Hoʻokumu ʻia ka BCR-ABL fusion gene ma ka unuhi ʻana ma waena o ka abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ma ka lima lōʻihi o ka chromosome 9 (9q34) a me ka ʻāpana puʻupuʻu breakpoint ( BCR) gene ma ka lima lōʻihi o ka chromosome 22 (22q11);ʻO ka fusion protein i hoʻopaʻa ʻia e kēia ʻano he hana tyrosine kinase (TK), a hoʻāla i kāna mau ala hōʻailona o lalo (e like me RAS, PI3K, a me JAK/STAT) e hāpai i ka māhele cell a keʻakeʻa i ka apoptosis cell, e hoʻonui nui ai nā cell, a ma laila e hoʻoulu ai. ka hiki ʻana mai o CML .ʻO BCR-ABL kekahi o nā hōʻailona diagnostics koʻikoʻi o CML.ʻO ka hoʻololi ikaika o kona pae transcript he hōʻailona hilinaʻi no ka hoʻoholo wānana o ka maʻi leukemia a hiki ke hoʻohana ʻia e wānana i ka hoʻi hou ʻana o ka maʻi leukemia ma hope o ka mālama ʻana.

Kanal

FAM BCR-ABL fusion gene
VIC/HEX Hoomalu Kuloko

Nā ʻāpana ʻenehana

Waihona Ka wai: ≤-18 ℃ I ka pōʻeleʻele
Kau-ola Ka wai: 9 mahina
ʻAno Hoʻohālike Nā laʻana o ka iwi iwi
LoD 1000 Kope/ mL

kikoo

 

ʻAʻohe mea hoʻopā kea me nā genes hui ʻē aʻe TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, a me PML-RARa
Nā mea hana pili Hoʻohana ʻia Biosystems 7500 Pūnaehana PCR manawa maoli

Hoʻohana ʻia ʻo Biosystems 7500 Fast Real-Time PCR Systems

QuantStudio® 5 Pūnaehana PCR Manawa maoli

SLAN-96P Pūnaehana PCR Manawa maoli

LightCycler®480 Pūnaehana PCR manawa maoli

LineGene 9600 Plus Pūnaehana ʻike PCR manawa maoli

MA-6000 ʻOiaʻiʻo ka nui o ka wela wela

BioRad CFX96 Pūnaehana PCR Manawa maoli

BioRad CFX Opus 96 Pūnaehana PCR Manawa maoli


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