Hoʻohui ʻia ʻo PCT/IL-6

ʻO PCT ka mua o ka calcitonin, he glycoprotein i haku ʻia me 116 amino acids.ʻO ka nui molekala ma kahi o 12.8kd.ʻAʻohe ona hana hormonal.Ma lalo o nā kūlana physiological, hoʻohui nui ʻia ka PCT a hūnā ʻia e nā cell thyroid C.I ka wā o ka maʻi bacteria, macrophages a me monocytes i loko o ke akepaʻa, lymphocytes a me nā pūnaewele endocrine i loko o ka māmā a me ka ʻiʻo ʻōpū e synthesize a hūnā i ka nui o ka PCT ma lalo o ka hana o endotoxin, tumor necrosis factor-α a me interleukin-6, e alakaʻi ana i kahi piʻi nui. i nā pae serum PCT.
ʻO Interleukin-6 kahi cytokine i hōʻike ʻia e ka ʻōnaehana pale kino i ka wā o ka hōʻeha mua a me ka maʻi.Hoʻokumu ʻia ia e nā fibroblasts, monocytes/macrophages, T lymphocytes, B lymphocytes, epithelial cell, keratinocytes, a me nā ʻāpana ʻokoʻa like ʻole.Aia ka IL-6 i ʻelua mau kaulahao glycoprotein, hoʻokahi kaulahao α me ke kaumaha molekala o 80kd;ʻo ka mea ʻē aʻe he kaulahao β me ke kaumaha molekala o 130kd[5].Inā hoʻoulu ʻia ke kino o ke kanaka e ka mumū, piʻi wikiwiki nā pae IL-6, ʻo ia ka mea e hoʻopili i ka pane o ka manawa acute o ke ake a hoʻoikaika i ka hana ʻana o nā protein acute phase e like me C-reactive protein (CRP) a me serum amyloid A (SAA). ).No laila, ʻo IL-6 ka hōʻailona mua loa e piʻi i ka wā e ulu ai ka mumū.