ʻO Clostridium Difficile Glutamate Dehydrogenase (GDH) a me ka Toxin A/B

ʻO Clostridium difficile (CD) kahi bacillus gram-positive anaerobic obligate, he flora maʻamau ia i loko o ke kino o ke kanaka. E kāohi ʻia nā flora ʻē aʻe mai ka hoʻonui ʻana ma muli o nā antibiotics i hoʻohana ʻia i nā nui nui, a hoʻopuka hou ʻo CD i loko o ke kino o ke kanaka i nā nui he nui. Ua māhele ʻia ʻo CD i nā ʻano hana toxin a me nā ʻano hana ʻole toxin. Hoʻopuka nā ʻano CD āpau i ka glutamate dehydrogenase (GDH) i ka wā e hoʻopuka hou ai lākou, a ʻo nā ʻano toxigenic wale nō ka pathogenic. Hiki i nā ʻano hana toxin ke hana i ʻelua mau toxins, ʻo A a me B. ʻO Toxin A kahi enterotoxin, hiki ke hoʻoulu i ka mumū o ka paia ʻōpū, ka infiltration cell, ka hoʻonui ʻana i ka permeability o ka paia ʻōpū, ka hemorrhage a me ka necrosis. ʻO Toxin B kahi cytotoxin, e hōʻino ana i ka cytoskeleton, ke kumu o ka pyknosis cell a me ka necrosis, a hōʻino pololei i nā cell parietal ʻōpū, e hopena ana i ka diarrhea a me ka pseudomembranous colitis.