ʻO Clostridium Difficile Glutamate Dehydrogenase(GDH) a me Toxin A/B

ʻO Clostridium difficile (CD) he bacillus anaerobic gram-positive obligate, he mea ulu maʻamau i loko o ke kino kanaka. E pale ʻia nā mea kanu ʻē aʻe mai ka hoʻomāhuahua ʻana ma muli o nā lāʻau antibiotic i hoʻohana ʻia i nā ʻano nui, a hana hou ʻo CD i loko o ke kino kanaka i ka nui. Hoʻokaʻawale ʻia ʻo CD i nā ʻano mea hoʻohua a me nā ʻano mea ʻole. Hoʻopuka nā ʻano CD āpau i ka glutamate dehydrogenase (GDH) i ka wā e hana hou ai lākou, a ʻo nā maʻi toxigenic wale nō ka pathogenic. Hiki ke hoʻohua i ʻelua mau mea ʻawaʻawa, ʻo A a me B. ʻO ka Toxin A he enterotoxin, hiki ke hoʻoulu i ka mumū o ka paia o ka ʻōpū, ka infiltration cell, hoʻonui i ka permeability o ka pā o ka ʻōpū, ka hemorrhage a me ka necrosis. ʻO ka Toxin B he cytotoxin, ka mea e hōʻino ai i ka cytoskeleton, ke kumu o ka pyknosis cell a me ka necrosis, a hoʻopōʻino pololei i nā pūpū parietal intestinal, ka hopena o ka maʻi maʻi a me ka pseudomembranous colitis.