ʻO Clostridium Difficile Glutamate Dehydrogenase(GDH) a me Toxin A/B

ʻO Clostridium difficile (CD) he bacillus anaerobic gram-positive obligate, he mea ulu maʻamau i loko o ke kino kanaka.E ʻae ʻia nā pua ʻē aʻe mai ka hoʻonui ʻana ma muli o nā lāʻau antibiotic i hoʻohana ʻia i nā ʻano nui, a hoʻopuka hou ʻia ka CD i loko o ke kino o ke kanaka i ka nui.Hoʻokaʻawale ʻia ʻo CD i nā ʻano mea hoʻohua a me nā ʻano mea ʻole.Hoʻopuka nā ʻano CD āpau i ka glutamate dehydrogenase (GDH) i ka wā e hana hou ai lākou, a ʻo nā maʻi toxigenic wale nō ka pathogenic.Hiki i nā mea hoʻoheheʻe i nā meaʻawaʻawa ke hana iʻelua mau meaʻawaʻawa, A a me B. ʻO ka Toxin A he enterotoxin, hiki ke hoʻoulu i ka mumū o ka paia o ka'ōpū, ke komoʻana o ke kino, ka piʻiʻana o ka pā o ka'ōpū, ka hemorrhage a me ka necrosis.He cytotoxin ka Toxin B, ka mea e hoʻopōʻino ai i ka cytoskeleton, ke kumu o ka pyknosis cell a me ka necrosis, a hoʻopōʻino pololei i nā pūnaewele parietal intestinal, ka hopena i ka maʻi maʻi a me ka pseudomembranous colitis.