Ka Hoʻololi ʻana o ke Kino Hoʻohuihui BCR-ABL Kanaka
Inoa huahana
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
HWTS-GE016A-Pahu ʻIke Hoʻololi Gene Fusion BCR-ABL Kanaka i hoʻomaloʻo ʻia (Fluorescence PCR)
ʻAlapia
ʻO ka maʻi myelogenous leukemia mau (CML) kahi maʻi clonal malignant o nā cell kumu hematopoietic. ʻOi aku ma mua o 95% o nā maʻi CML e lawe ana i ka chromosome Philadelphia (Ph) i loko o kā lākou mau cell koko. ʻO ka pathogenesis nui o CML penei: Hoʻokumu ʻia ka gene fusion BCR-ABL e kahi translocation ma waena o ka abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ma ka lima lōʻihi o ka chromosome 9 (9q34) a me ka gene breakpoint cluster region (BCR) ma ka lima lōʻihi o ka chromosome 22 (22q11); ʻo ka protein fusion i hoʻopili ʻia e kēia gene he tyrosine kinase (TK) ka hana, a hoʻāla i kona mau ala hōʻailona ma lalo (e like me RAS, PI3K, a me JAK/STAT) e hoʻolaha i ka mahele cell a kāohi i ka apoptosis cell, e hoʻonui ana i nā cell i ka malignantly, a pēlā e hoʻoulu ai i ka hanana ʻana o CML. ʻO BCR-ABL kekahi o nā hōʻailona diagnostic koʻikoʻi o CML. ʻO ka loli ikaika o kona pae transcript he hōʻailona hilinaʻi ia no ka hoʻoholo prognostic o ka leukemia a hiki ke hoʻohana ʻia e wānana i ka hoʻi hou ʻana o ka leukemia ma hope o ka mālama ʻana.
Kanal
| ʻOhana | ʻO ke kine hoʻohuihui BCR-ABL |
| VIC/HEX | Mana Kūloko |
Nā Palena ʻenehana
| Ka Waihona | Wai: ≤-18 ℃ I ka pōʻeleʻele |
| Ola papa | Wai: 9 mahina |
| ʻAno Laʻana | Nā hāpana iwi |
| LoD | 1000 Kope/mL |
| Kūlana kikoʻī
| ʻAʻohe cross-reactivity me nā genes fusion ʻē aʻe ʻo TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, a me PML-RARa |
| Nā Mea Hana Pili | Nā ʻōnaehana Biosystems i hoʻopili ʻia 7500 Nā ʻōnaehana PCR Manawa Maoli Nā ʻōnaehana PCR manawa maoli wikiwiki Biosystems i hoʻopili ʻia 7500 Nā ʻōnaehana PCR Manawa Maoli QuantStudio® 5 Nā ʻōnaehana PCR Manawa Maoli SLAN-96P ʻŌnaehana PCR Manawa Maoli LightCycler®480 ʻŌnaehana ʻIke PCR Manawa Maoli LineGene 9600 Plus MA-6000 Mea Hoʻopololei Wela Manawa Maoli ʻŌnaehana PCR Manawa Maoli BioRad CFX96 ʻŌnaehana PCR Manawa Maoli BioRad CFX Opus 96 |
