Kanaka cyp2c9 a me V VIWC1 WYCOM1 WYCOMORPHIMS
Hua waihona
Hwts-ge014a-kanaka cyp2c9 a me Vinwc1 Gene polymorphism Kat (Fluorescence PCr)
HAAKAANA
Ce / tfda
Epideminey
ʻO Warfarin kahi hana maʻamau maʻamau i hoʻohana pinepineʻia i ka hoʻomaʻamaʻaʻana i kēia manawa,ʻo ia ka mea nui i manaʻoʻia no ka paleʻana a me ka mālamaʻana i nā maʻi thrombox. Eia nō naʻe, he mau kaua o Warfarin i ka puka makani i kaupalenaʻia a me nāʻano likeʻole ma waena o nā lāhui likeʻole. Ua hōʻikeʻia nā helu helu i kaʻokoʻa o keʻano o keʻano o nā mea i hiki keʻoi aku ma mua o 20 mau manawa. ʻO keʻano o keʻano o ke alohaʻana i ka wā e hele ai i 15.2% o nā mea maʻi e lawe ana i kēlā me kēia makahiki,ʻo ia ka mea 3.5% e hoʻomohala ai i ka momona momona. Ua hōʻikeʻo Pharmacogenomisnominmic ʻO Warfarin kahi mea inoibitis kūikawā o ka nui o ka nui o ka nui o ka hua waina: Ua hōʻikeʻia kahi nui o nā haʻawina e hōʻike anaʻo ka pymorphorism o ka phymomphism a Vlorc1 promor ka mea nui e pili ana i ka lāhui ʻO Warfarin ka metabilin e cyp2c9, a me kona mau mutants e hoʻolōʻihi i ka metabolism o Warfarin. Loaʻa i nā poʻe kanaka ke hoʻohana i ke kaua i loaʻa i kahi kiʻekiʻe kiʻekiʻe (ʻelua mau manawa iʻekolu mau manawa kiʻekiʻe) o ke kaheʻana i keʻano mua o ka hoʻohana muaʻana.
Kauwe
| Ka ha | Shrrc1 (-1639g> a) |
| Kūpono Kakau | Cyp2c9 * 3 |
| VIC / Hex | IC |
Nā poʻoaʻenehana
| Huanui | Wai: ≤-18 ℃ |
| 'Āmaʻomaʻo | 12 mau mahina |
| ʻAno kiko'ī | ʻO ke koko aʻoi akuʻo Edta Anticoagulated |
| CV | ≤5.0% |
| Lolulu | 1.0ng / μl |
| Kiko'ī | ʻAʻohe mea e hana hou ai me nāʻano'ē aʻe e like me nāʻano likeʻole o ke kanaka genome mika o cyp2c9 * 13 a me vhorc1 (3730G> A) ma waho o kaʻike o kēia pahu |
| Nā mea pili | Noi biosysteystems 7500 mau'ōnaehana PCR Noi biosystems 7500 wikiwiki mau'ōnaehana PCR ʻO ka helu helu RETSTATIDO®5 i nā'ōnaehana PCR manawa SLAN-96P mea maoli maoli PCR ʻO Lightcycler®480 Reass-Time Systems PCR Linegene 9600 a me ka'ōnaehanaʻo PCR maoli Ma-6000 maoli-manawa nui ka manawa nui Biorad CFX96 Nā Kūlana Kūlana Lacr Biorad CFX OPus 96 Reass PCR System |
Nā kahe o ka hana
Hoʻonohonohoʻia nā uku uku 3006).
