ʻO ke kanaka CYP2C9 a me VKORC1 Gene Polymorphism

ʻO ka wehewehe pōkole:

Pili kēia kit i ka in vitro qualitative detection of polymorphism o CYP2C9*3 (rs1057910, 1075A>C) a me VKORC1 (rs9923231, -1639G>A) i loko o ka genomic DNA o ke kanaka holookoa koko samples.


Huahana Huahana

Huahana Huahana

Inoa mea kūʻai

HWTS-GE014A-Human CYP2C9 a me VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)

Palapala

CE/TFDA

Epidemiology

ʻO Warfarin kahi anticoagulant waha i hoʻohana mau ʻia i ka hoʻomaʻamaʻa lapaʻau i kēia manawa, i manaʻo nui ʻia no ka pale ʻana a me ka mālama ʻana i nā maʻi thromboembolic.Eia nō naʻe, ʻokoʻa ka warfarin ma waena o nā lāhui a me nā kānaka like ʻole.Ua hōʻike ʻia nā helu helu hiki ke ʻoi aku ka ʻokoʻa o ka maʻa paʻa i nā poʻe like ʻole ma mua o 20 mau manawa.Loaʻa ka hopena maikaʻi ʻole i ke koko ma 15.2% o nā mea maʻi e lawe ana i ka warfarin i kēlā me kēia makahiki, kahi o 3.5% e hoʻomohala i ke koko make.Ua hōʻike ʻia nā haʻawina Pharmacogenomic ʻo ka genetic polymorphism o ka enzyme target VKORC1 a me ka metabolic enzyme CYP2C9 o warfarin he mea nui e pili ana i ka ʻokoʻa o ka nui o ka warfarin.ʻO Warfarin kahi mea paʻa pono o ka vitamin K epoxide reductase (VKORC1), a no laila ke kāohi nei i ka synthesis factor clotting e pili ana i ka huaora K a hāʻawi i ka anticoagulation.Ua hōʻike ʻia kahi helu nui o nā haʻawina ʻo ka polymorphism gene o ka mea hoʻolaha VKORC1 ka mea nui e pili ana i ka lāhui a me nā ʻokoʻa o kēlā me kēia kanaka i ka nui o ka warfarin.Hoʻopili ʻia ʻo Warfarin e CYP2C9, a ʻoi aku ka lohi o kāna mau mutants i ka metabolism o warfarin.ʻO ka poʻe e hoʻohana ana i ka warfarin, ʻoi aku ka nui o ka pilikia (ʻelua a ʻekolu mau manawa kiʻekiʻe) o ke koko i ka wā mua o ka hoʻohana ʻana.

Kanal

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Nā ʻāpana ʻenehana

Waihona Ka wai: ≤-18 ℃
Kau-ola 12 mahina
ʻAno Hoʻohālike Ke koko anticoagulated EDTA hou
CV ≤5.0%
LoD 1.0ng/μL
kikoo ʻAʻohe hoʻololi keʻa me nā kaʻina like ʻole o ka genome kanaka (gene CYP2C19 kanaka, gene RPN2 kanaka);ka hoʻololi ʻana o CYP2C9*13 a me VKORC1 (3730G>A) ma waho o ka pae ʻike o kēia pahu.
Nā mea hana pili Hoʻohana ʻia Biosystems 7500 Pūnaehana PCR manawa maoli

Hoʻohana ʻia ʻo Biosystems 7500 Fast Real-Time PCR Systems

QuantStudio®5 Pūnaehana PCR Manawa maoli

SLAN-96P Pūnaehana PCR Manawa maoli

LightCycler®480 Pūnaehana PCR manawa maoli

LineGene 9600 Plus Pūnaehana ʻike PCR manawa maoli

MA-6000 ʻOiaʻiʻo ka nui o ka wela wela

BioRad CFX96 Pūnaehana PCR Manawa maoli

BioRad CFX Opus 96 Pūnaehana PCR Manawa maoli

Holo Hana

Manaʻo ʻia ka hoʻihoʻi ʻana: Macro & Micro-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) a me Macro & Micro-Test Automatic Nucleic Acid Extractor(HWTS- 3006).


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