ʻO ka waikawa nucleic Cytomegalovirus kanaka (HCMV)

ʻO ka cytomegalovirus kanaka (HCMV) kahi lālā me ka genome nui loa i ka ʻohana herpes virus a hiki ke hoʻopili ma mua o 200 mau protein. Ua kaupalena iki ʻia ka HCMV i loko o kona wahi kikowaena i nā kānaka, a ʻaʻohe kumu hoʻohālike holoholona o kona maʻi. He pōʻaiapuni replication lohi a lōʻihi ko HCMV e hana i kahi kino hoʻokomo intranuclear, a hoʻoulu i ka hana ʻana o nā kino hoʻokomo perinuclear a me cytoplasmic a me ka pehu ʻana o nā cell (nā cell nunui), no laila ka inoa. Wahi a ka heterogeneity o kona genome a me ka phenotype, hiki ke hoʻokaʻawale ʻia ʻo HCMV i nā ʻano ʻano like ʻole, aia kekahi mau ʻano antigenic, akā naʻe, ʻaʻohe koʻikoʻi lapaʻau.

ʻO ka maʻi HCMV kahi maʻi ʻōnaehana, kahi e pili ana i nā ʻōpū he nui, he mau hōʻailona paʻakikī a like ʻole, ʻaʻole nui ka leo, a hiki ke hoʻoulu i kekahi mau maʻi e hoʻomohala i nā ʻeha ʻōpū he nui e like me ka retinitis, hepatitis, pneumonia, encephalitis, colitis, monocytosis, a me ka thrombocytopenic purpura. He mea maʻamau loa ka maʻi HCMV a ʻike ʻia e pālahalaha ana ma ka honua holoʻokoʻa. He mea laha loa ia i ka heluna kanaka, me nā helu hanana o 45-50% a ʻoi aku ma mua o 90% ma nā ʻāina i hoʻomohala ʻia a me nā ʻāina e ulu ana. Hiki i ka HCMV ke moe i loko o ke kino no ka manawa lōʻihi. Ke hoʻonāwaliwali ʻia ka pale ʻana o ke kino, e hoʻāla ʻia ka maʻi e hoʻoulu i nā maʻi, ʻoi aku ka maʻi hou i nā maʻi leukemia a me nā maʻi transplant, a hiki ke hoʻoulu i ka necrosis o ka ʻōpū transplanted a hoʻoweliweli i ke ola o nā maʻi i nā hihia koʻikoʻi. Ma waho aʻe o ka hānau ʻana, ka hāʻule ʻana o ka ʻōpū a me ka hānau mua ʻana ma o ka maʻi intrauterine, hiki i ka cytomegalovirus ke hoʻoulu i nā maʻi congenital, no laila hiki i ka maʻi HCMV ke hoʻopilikia i ka mālama prenatal a me ka postnatal a me ka maikaʻi o ka heluna kanaka.