Ka Hoʻololi ʻana o ke Kino Huihui ROS1 Kanaka

ʻO ROS1 kahi tyrosine kinase transmembrane o ka ʻohana receptor insulin. Ua hōʻoia ʻia ka gene fusion ROS1 ʻo ia kekahi gene hoʻokele maʻi kanesa māmā ʻaʻole liʻiliʻi. Ma ke ʻano he ʻelele o kahi ʻano molekala hou kū hoʻokahi, ʻo ka nui o ka gene fusion ROS1 ma NSCLC Ma kahi o 1% a 2% ROS1 e hana nui ʻia ka hoʻonohonoho hou ʻana o nā gene ma kāna mau exons 32, 34, 35 a me 36. Ma hope o ka hoʻohui ʻia ʻana me nā genes e like me CD74, EZR, SLC34A2, a me SDC4, e hoʻomau ia i ka hoʻoulu ʻana i ka ʻāpana ROS1 tyrosine kinase. Hiki i ka ROS1 kinase i hoʻoulu ʻia i ka maʻamau ʻole ke hoʻoulu i nā ala hōʻailona ma lalo e like me RAS/MAPK/ERK, PI3K/Akt/mTOR, a me JAK3/STAT3, no laila e komo ana i ka hoʻonui ʻana, ka hoʻokaʻawale ʻana a me ka metastasis o nā cell tumor, a me ke kumu o ka maʻi kanesa. Ma waena o nā hoʻololi fusion ROS1, ʻo CD74-ROS1 ka helu no kahi 42%, ʻo EZR ka helu no kahi 15%, ʻo SLC34A2 ka helu no kahi 12%, a ʻo SDC4 ka helu no kahi 7%. Ua hōʻike ʻia nā haʻawina he homology a hiki i ka 77% ka pūnaewele hoʻopaʻa ATP o ka catalytic domain o ROS1 kinase a me ka pūnaewele hoʻopaʻa ATP o ALK kinase, no laila he hopena hōʻoluʻolu maopopo ka ALK tyrosine kinase small molecule inhibitor crizotinib a pēlā aku i ka mālama ʻana iā NSCLC me ka hoʻololi fusion o ROS1. No laila, ʻo ka ʻike ʻana i nā hoʻololi fusion ROS1 ke kumu a me ke kumu no ke alakaʻi ʻana i ka hoʻohana ʻana i nā lāʻau crizotinib.