ʻO ka waikawa nukleika polymorphic gene MTHFR

ʻO ka waikawa Folic kahi huaora wai-hoʻoheheʻe ʻia he cofactor koʻikoʻi i nā ala metabolic o ke kino. I nā makahiki i hala iho nei, ua hōʻoia ka nui o nā haʻawina, ʻo ka mutation o ka gene enzyme metabolizing folate MTHFR e alakaʻi i ka nele o ka waikawa folic i loko o ke kino, a ʻo ka hōʻino maʻamau o ka nele o ka waikawa folic i nā pākeke e hiki ke hana i ka anemia megaloblastic, ka hōʻino ʻana o ka endothelial vascular, a me nā mea ʻē aʻe. ʻAʻole hiki i ka nele o ka waikawa folic i nā wahine hāpai ke hoʻokō i nā pono o lākou iho a me ka fetus, hiki ke hana i nā kīnā neural tube, anencephaly, stillbirth, a me ka miscarriage. Hoʻopilikia ʻia nā pae folate serum e nā polymorphisms 5,10-methylenetetrahydrofolate reductase (MTHFR). ʻO nā mutations 677C>T a me 1298A>C i loko o ka gene MTHFR e hoʻohuli i ka hoʻololi ʻana o ka alanine i valine a me ka glutamic acid, kēlā me kēia, e hopena ana i ka emi ʻana o ka hana MTHFR a no laila ua emi ka hoʻohana ʻana o ka waikawa folic.