Kanaka Methylated NDRG4/SEPT9/SFRP2/BMP3/SDC2 Gene

I ka poe makua, oi aku mamua o 10 8 intestinal epithelial cell haule mai ka intestinal paia kela la i keia la, a ua excreted me ka feces ma o ka nui opu peristalsis.Ma muli o ka hāʻule ʻana o ka ʻōpū mai ka ʻāpana ʻōpū o ka hoʻonui ʻole ʻia, ʻo ka ʻōpala o nā mea maʻi maʻi ʻōpū he nui nā maʻi maʻi a me nā ʻāpana cell abnormal, ʻo ia ke kumu kumu no ka ʻike ʻana i ka stool paʻa.Ua ʻike ʻia nā haʻawina ʻo ka hoʻololi ʻana i ka methylation o nā mea hoʻolaha gene he hanana mua ia i ka tumorigenesis, a ʻo nā mea genetic i loaʻa mai nā ʻāpana o nā mea maʻi maʻi maʻi colorectal hiki ke hōʻike i ka hele ʻana o ka maʻi kanesa i loko o ka ʻōpū ma mua.

ʻO NDRG4, i kapa ʻia ʻo SMAP-8 a me BDM1, ʻo ia kekahi o nā lālā ʻehā o ka ʻohana gene NDRG (NDRG1-4), i hōʻike ʻia e pili ana i ka hoʻonui ʻana o ka cell, ka ʻokoʻa, ka ulu ʻana a me ke kaumaha.Ua hōʻoia ʻia ʻo ka NDRG4 methylation kahi mea biomarker no ka ʻike ʻole ʻana i ka maʻi maʻi colorectal ma nā ʻāpana stool.

He lālā ʻo SEPT9 o ka ʻohana gene Septin, nona ka liʻiliʻi he 13 mau genes e hoʻopili ai i kahi kikowaena GTPase mālama ʻia e hiki ke hoʻopaʻa i nā protein pili cytoskeleton, a pili pū me ka māhele cell a me ka tumorigenesis.Ua ʻike ʻia nā haʻawina ua hoʻonui nui ʻia ka maʻi gen methylated Septin9 i nā laʻana stool mai nā maʻi me ka maʻi maʻi colorectal.

ʻO nā protein pili i pili i ka frizzled huna (sFRPs) he mau polokina hiki ke hoʻoheheʻe ʻia he papa o nā antagonists ala Wnt ma muli o kā lākou homology kiʻekiʻe i ka mea hoʻokipa frizzled (Fz) no ka hōʻailona Wnt.ʻO ka inactivation o ka SFRP gene ka hopena i ka hoʻōla ʻole ʻia o ka hōʻailona Wnt pili me ka maʻi maʻi colorectal.I kēia manawa, hiki ke hoʻohana ʻia ka SFRP2 methylation i loko o ka stool ma ke ʻano he biomarker non-invasive no ka ʻike ʻana i ka maʻi maʻi colorectal.

He lālā ʻo BMP3 o ka ʻohana super TGF-B a no laila he kuleana koʻikoʻi i ka ulu ʻana o ka embryonic ma o ka hoʻoulu ʻana a me ka hoʻohua ʻana i ka iwi mua.ʻO ka BMP3 ka hypermethylated i ka maʻi maʻi colorectal a hiki ke hoʻohana ʻia ma ke ʻano he hōʻailona koʻikoʻi.

ʻO SDC2 kahi proteoglycan heparan sulfate ma luna o ke kelepona i komo i ka hoʻoponopono ʻana i nā kaʻina hana physiological a me nā pathological.ʻO ke kino i hana ʻia me ka hoʻonui ʻana o ka cell, ka ʻokoʻa, ka adhesion, ka hui cytoskeletal, ka neʻe ʻana, ka hoʻōla ʻana i ka ʻeha, ke kamaʻilio cell-matrix, angiogenesis;ʻO nā kaʻina hana pathological e pili ana i ka mumū a me ke kanesa.ʻOi aku ka kiʻekiʻe o ka pae methylation o ka gene SDC2 i loko o nā ʻiʻo maʻi maʻi colorectal ma mua o nā mea maʻamau.