Kanaka CYP2C19 Gene Polymorphism

ʻO CYP2C19 kekahi o nā enzyme metabolizing lāʻau nui i ka ʻohana CYP450. ʻO ka nui o nā substrates endogenous a ma kahi o 2% o nā lāʻau lapaʻau e metabolized e CYP2C19, e like me ka metabolism o ka antiplatelet aggregation inhibitors (e like me clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, a pēlā aku. ʻO kēia mau helu hoʻololi o *2 (rs4244285) a me *3 (rs4986893) ke kumu i ka nalowale o ka hana enzyme i hoʻopaʻa ʻia e ka CYP2C19 gene a me ka nāwaliwali o ka hiki ke substrate metabolic, a hoʻonui i ke kahe koko, i mea e hoʻopilikia ai i ka lāʻau lapaʻau e pili ana i ke koko. *17 (rs12248560) hiki ke hoʻonui i ka hana enzyme i hoʻopaʻa ʻia e CYP2C19 gene, ka hana ʻana o nā metabolites ikaika, a hoʻonui i ka pale ʻana i ka platelet aggregation a hoʻonui i ka pilikia o ke koko. No ka poʻe me ka lohi o ka metabolism o nā lāʻau lapaʻau, ʻo ka lawe ʻana i nā maʻi maʻamau no ka manawa lōʻihi e hopena i nā hopena koʻikoʻi a me nā hopena ʻaoʻao: ʻo ka nui o ka pōʻino o ka ate, ka pōʻino o ka ʻōnaehana hematopoietic, ka pōʻino o ka ʻōnaehana nerve waena, etc., hiki ke alakaʻi i ka make i nā hihia koʻikoʻi. Wahi a nā ʻokoʻa o kēlā me kēia kanaka i ka lāʻau lapaʻau e pili ana, ua māhele ʻia i ʻehā phenotypes, ʻo ia hoʻi ka ultra-fast metabolism (UM, * 17 / * 17, * 1 / * 17), ka wikiwiki wikiwiki (RM, * 1 / * 1), ka waena waena (IM, * 1 / * 2, * 1 / * 3), lohi ka metabolism (PM, * 2 / * 2, * 3 / * 3, * 2 / * 3).