ʻO ka Polymorphism Gene CYP2C19 kanaka

ʻO CYP2C19 kekahi o nā enzyme metabolizing lāʻau koʻikoʻi i loko o ka ʻohana CYP450. He nui nā substrates endogenous a ma kahi o 2% o nā lāʻau lapaʻau i metabolized e CYP2C19, e like me ka metabolism o nā antiplatelet aggregation inhibitors (e like me clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, etc. Loaʻa pū kekahi ʻokoʻa o nā polymorphisms gene CYP2C19 i ka hiki ke metabolizing o nā lāʻau pili. ʻO kēia mau mutations point o *2 (rs4244285) a me *3 (rs4986893) ke kumu o ka nalowale ʻana o ka hana enzyme i hoʻopili ʻia e ka gene CYP2C19 a me ka nāwaliwali o ka hiki ke metabolic substrate, a hoʻonui i ka nui o ke koko, i mea e hoʻoulu ai i nā hopena lāʻau maikaʻi ʻole e pili ana i ka nui o ke koko. Hiki i ka *17 (rs12248560) ke hoʻonui i ka hana enzyme i hoʻopili ʻia e ka gene CYP2C19, ka hana ʻana o nā metabolites hana, a hoʻonui i ka pale ʻana o ka platelet aggregation a hoʻonui i ka pilikia o ke kahe koko. No ka poʻe me ka lohi o ka metabolism o nā lāʻau lapaʻau, ʻo ka lawe ʻana i nā lāʻau maʻamau no ka manawa lōʻihi e hoʻoulu ai i nā hopena ʻawaʻawa a me nā hopena ʻaoʻao: ʻo ka hapa nui o ka hōʻino ʻana o ke akepaʻa, ka hōʻino ʻana o ka ʻōnaehana hematopoietic, ka hōʻino ʻana o ka ʻōnaehana nerve waena, a me nā mea ʻē aʻe, hiki ke alakaʻi i ka make i nā hihia koʻikoʻi. Wahi a nā ʻokoʻa pilikino i ka metabolism lāʻau lapaʻau like, ua māhele ʻia i ʻehā mau ʻano, ʻo ia hoʻi ka metabolism wikiwiki loa (UM,*17/*17,*1/*17), metabolism wikiwiki (RM,*1/*1), metabolism waena (IM, *1/*2, *1/*3), metabolism lohi (PM, *2/*2, *2/*3, *3/*3).